PHARMACOLOGICAL STUDIES ON NITROGEN MUSTARD-N-OXIDES , ,

Studies on the N-dealkylation of nitrogen mustard and triethylenemelamine by liver homogenates.

administration, most of the radioactivity appeared in the urine during the same period. Comparison of specific activities and differential distribution ra tios in organs after short-term and long-term ex periments with either drug indicated a selective uptake of radioactivity by liver, kidneys, and lungs immediately after administration. No selec tive uptake, however, was observed in any tissue...

Studies on vaccinia hemagglutinin. IV. On the effect of nitrogen mustard on vaccinia hemagglutinin.

Many works were made on the biological application of mustard gas and nitrogen mustard. The mechanism of the biological action of mustards , however, remains largely unknown, and many experimental results have been accumulated to, suggest its mode of actions(1) , among which much attention has been called to the analogy of its action to those of X-ray irradiation or of hydrogen peroxide(2). Her...

Indoor Nitrogen Oxides

Nitrogen monoxide (NO) and nitrogen dioxide (NO2) are gases produced by hightemperature combustion through reactions between nitrogen and oxygen. Both nitrogen in fuel and nitrogen in the air can participate in the reactions. Formation of NO can be followed by further oxidation into NO2 in the atmosphere. NO2 is the most toxic of the nitrogen oxides (grouped generically as NOx) and it is very i...

Control of Nitrogen Oxides

Evidence for a Transport Carrier of Nitrogen Mustard in Nitrogen Mustard-sensitive and -resistant L5178Y Lymphoblasts1

inhibited by ouabain and 2,4-dinitrophenol. These findings suggest that transport of HN2 is carrier-mediated and is an active process. The Km for resistant cells was higher than that of sensitive cells, suggesting a decreased affinity of the trans port carrier for drug. The Vmax of resistant cells was lower than that of sensitive lymphoblasts, suggesting decreased trans port capacity in resista...